Manchester United will welcome Chelsea to Old Trafford, in their first fixture of the 2019/2020 season, after the Premier League unveiled the fixture list on Wednesday.
Manchester United finished sixth in the League table last season, while Chelsea ended up in third place.
Other fixtures will see Newcastle United welcome Arsenal, Aston Villa travel to Tottenham Hotspur and Liverpool host new comers Norwich.
However, Champions Manchester City begin defence of their title at West Ham.
The new EPL season kicks off August 8, 2019.
Opening day fixtures:
Crystal Palace vs Everton
Watford vs Brighton
Leicester City vs Wolves
Burnley vs Southampton
Bournemouth vs Sheffield United
Newcastle vs Arsenal
Manchester United vs Chelsea
West Ham vs Manchester City
Tottenham vs Aston Villa
Liverpool vs Norwich